Iso-dC and Iso-dG
Iso-dG and Iso-dC are novel DNA bases licensed from EraGen Biosciences, Inc (www.eragen.com). Iso-dC and Iso-dG are chemical variants of cytosine and guanine, respectively. Iso-dC will hydrogen bond with Iso-dG but not with dG. Similarly, Iso-dG will base pair with Iso-dC but not with dC.1 Incorporation of these novel bases into DNA effectively expands the genetic alphabet and permits synthesis of oligonucleotides that have increased specificity and decreased mismatch hybridization potential. For example, an oligonucleotide containing Iso-dC can be designed so that it will hybridize to a complementary oligo containing Iso-dG but will not hybridize to any naturally occurring nucleic acids sequence. Oligonucleotides that contain either or both iso-bases require IE-HPLC purification.
Scientific Details
Mod Code: /5isodG/
 
 
 
Scientific Details
Mod Code: /iisodG/
 
 
 
 
Structure
Structure
 
 
Scientific Details
MW: 14
Mod Code: /5Me-isodC/
 
 
 
 
 
Scientific Details
MW: 14
Mod Code: /iMe-isodC/
 
 
 
 
 
Structure
Structure
 
 

 

 
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