Nucleotides

One of the main reasons for the success of IBA in custom oligonucleotide and dinucleotide synthesis is the in-house nucleic acid chemistry facility. It enables us to provide modified oligonucleotides in top quality at competitive prices.

IBA can in principle synthesize any modified nucleosidic and non-nucleosidic compound that is required.

Consequently, IBA has extensive expertise in:

Synthesis of modified nucleosides and nucleotides
Synthesis of special amidites
Synthesis of non-nucleosidic compounds including linkers, dyes etc.
Immobilization of nucleic acids, peptides, and proteins on solid phases

Nucleotides peresently available as pre-defined products are

RNA dinucleotides

IBA is offering all possible combinations of RNA dinucleotides as stock items.

	A	C	G	U
A	X	X	X	X
C	X	X	X	X
G	X	X	X	X
U	X	X	X	X

DNA dinucleotides are also available on request!

Modified dinucleotides for 5' transcript labeling: Transcription starters

A unique product line only available at IBA

5'-Modified ApG can be used in in vitro transcription experiments. It is incorporated only once at the 5'-end. By using this compound it is easy to either introduce fluorescent markers to make transcripts visible, or non-radioactive markers like biotin or digoxigenin to isolate transcription products. In principle all of the available dyes and non-radioactive reporter groups can be introduced. Please inquire for more information.