IDT
IDT
xGen® Exome Research Panel v2 Deep, uniform coverage of the human exome with best-in-class capture panel Go ahead and commit. We made a lot. We designed this updated panel using our new target-aware algorithm, resulting in the most complete coverage of any exome panel on the market. We assessed each probe with proprietary off-target analysis and manufactured them under strict ISO 13485 standards. We performed electrospray ionization mass spectrometry (ESI-MS) and dual quantification on each of the 415,115 probes before pooling. Finally, individual probe synthesis means we can deliver on a much larger scale than array methods, and produce a single large lot that can be aliquoted and stored securely, for years of reproducibility. The xGen Exome Research Panel v2 gives you the confidence that only individual probe synthesis and individual QC can provide, and it comes at a price that makes your choice easy.
xGen Exome Research Panel v2
Interested in a volume discount? Contact us. For customers who wish to purchase the legacy xGen Exome Research Panel v1.0, please contact customquotes@idtdna.com.
The xGen Exome Research Panel v1.0 consists of 429,826 GMP compliant, individually synthesized, and quality controlled xGen Lockdown® Probes spanning a 39 Mb target region of the human genome covered by 51 Mb of end-to-end tiled space. The xGen AML Cancer Panel v1.0 comprises 11,743 xGen Lockdown® Probes, spanning 1.19 Mb of the human genome, for targeted enrichment of >260 genes associated with the AML to provide more efficient detection of disease-causing mutations. The xGen Pan-Cancer Panel v1.5 consists of 7816 xGen Lockdown® Probes, spanning 800 kb of the human genome, that capture 127 significantly mutated genes implicated across 12 tumor types for deeper sequencing coverage. The xGen Inherited Diseases Panel v1.0 consists of 116,355 xGen Lockdown® Probes, spanning 11.1 Mb of the human genome, designed for targeted enrichment of genes and SNPs associated with inherited diseases. Inherited diseases panel details » The xGen Human ID Research Panel consists of 229 xGen Lockdown® Probes for targeted enrichment of a definitive set of single nucleotide polymorphisms (SNPs) selected to identify a unique individual from a population of over 5 million biological samples. The xGen Human mtDNA Research Panel provides of 138 xGen Lockdown® Probes for cost-effective and accurate detection of sequence variants in mitochondrial DNA. Supplementing xGen® Lockdown® PanelsxGen Lockdown Panels can be customized by supplementing with additional probes. When supplementing an xGen Lockdown Panel, it is important to add the new probes at the same molar concentration as the probes in the original pool. The following table lists the molar concentration of each probe for a single hybrid capture reaction.
For step-by-step instructions on how to supplement xGen Lockdown Panels with additional probes, contact contact our NGS technical support group at xgen@idtdna.com for the Probe Supplementation (Spike-In) Protocol. Performance GuaranteeAll products have been functionally tested using the protocol, Hybridization capture of DNA libraries using xGen Lockdown Probes and Reagents. Please contact IDT at xgen@idtdna.com for more information on tested protocols. BrochuresSupport |
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